How do GLP-1s work? These drugs increase insulin secretion, decrease glucagon (which raises blood sugar), and slow gastric emptying, making you feel full faster and longer.

What are common side effects? Common side effects include nausea, vomiting, diarrhea, constipation, and stomach pain, which are often most severe when first starting the medication.

What is the difference between Semaglutide and Tirzepatide? Semaglutide (Ozempic, Wegovy) acts on the GLP-1 receptor, while Tirzepatide (Mounjaro, Zepbound) acts on both GLP-1 and GIP receptors, which may lead to greater weight loss.

How much weight can I expect to lose? Clinical trials showed individuals with obesity (without diabetes) lost an average of 15-20% of their body weight over 68 weeks while on 2.4 mg of semaglutide.

Do I have to stay on them forever? While some people use them long-term, stopping the medication often results in regaining most of the lost weight, as appetite and cravings tend to return.

How are they taken? Most are once-weekly injections, but some, like Rybelsus, are daily tablets taken on an empty stomach.

What should I eat? It is recommended to follow a balanced, lower-calorie diet, as the medication is most effective when combined with lifestyle changes.

Are they safe? They are generally safe but have risks, including potential issues with the pancreas, gallbladder, kidneys, and, rarely, a risk of thyroid C-cell tumors (seen in rodents).